How LDN can help with pain
- Kevin Keane
- Oct 1, 2024
- 2 min read
Low dose naltrexone (LDN) has been explored for its potential benefits in treating various types of pain, particularly chronic pain conditions. Here’s how LDN may help with pain:
Mechanism of Action
1. Endorphin Production:
o LDN works by temporarily blocking opioid receptors, which leads to a rebound
increase in the production of endorphins (the body’s natural painkillers) when the
blockade is lifted. Increased endorphin levels can help alleviate pain.
2. Anti-inflammatory Effects:
o LDN has been shown to reduce inflammation by modulating the immune system.
It can decrease the production of pro-inflammatory cytokines and increase the
production of anti-inflammatory cytokines. This anti-inflammatory effect can help
reduce pain associated with inflammatory conditions.
3. Microglial Cell Modulation:
o LDN modulates the activity of microglial cells in the central nervous system.
Overactive microglial cells are associated with chronic pain and
neuroinflammation. By reducing their activity, LDN can help in alleviating pain.
4. Glial Cell Modulation:
o Similar to its effects on microglial cells, LDN can modulate other glial cells,
which play a role in pain signaling and inflammation in the nervous system.
Conditions Treated
1. Fibromyalgia:
o LDN has shown promise in reducing pain and improving quality of life in patients
with fibromyalgia.
2. Complex Regional Pain Syndrome (CRPS):
o Patients with CRPS have reported reductions in pain and improved functionality
with LDN.
3. Neuropathic Pain:
o LDN may help alleviate neuropathic pain, which can result from conditions such
as diabetes, multiple sclerosis, and nerve injuries.
4. Inflammatory Bowel Disease (IBD):
o In conditions like Crohn’s disease and ulcerative colitis, LDN has been reported
to reduce pain and other symptoms by reducing intestinal inflammation.
Dosage and Administration
o LDN is typically prescribed in doses ranging from 0.5 mg to 4.5 mg per day. The exact
dosage may vary based on the condition being treated and patient response.
o It is usually taken once daily, often at bedtime.
Safety and Side Effects
o LDN is generally well-tolerated. Common side effects, if they occur, are usually mild and may include vivid dreams, insomnia, and gastrointestinal discomfort.
o Because it is used at a much lower dose than that for its original use (opioid addiction),
the risk of significant side effects is minimal.
Research and Evidence
o Clinical studies and anecdotal evidence from patients and practitioners suggest that LDN can be an effective and safe treatment option for various chronic pain conditions.
o Ongoing research is needed to further establish its efficacy and safety profile across
different patient populations and pain conditions.
If considering LDN for pain management, it is important to consult with a healthcare provider to determine if it is appropriate for your specific condition and to establish the correct dosage and monitoring plan.
Written by:
Joseph Gagnon Jr.